DNA Metabolism, Genomic Stability and Diseases

Suzhou, China 
June 13-17, 2016  

Abstract Deadline: April 24, 2016

Conference Agenda

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Organized by:

Judith Campbell, California Institute of Technology, USA

Daochun Kong, Peking University, China

Binghui Shen, City of Hope, USA

Stephen West, The Francis Crick Institute, UK

We are pleased to announce the 1st Cold Spring Harbor Asia conference on DNA Metabolism, Genomic Stability and Diseases which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday June 13, and will conclude after lunch on June 17, 2016

The conference will include eight oral sessions and one poster session covering the latest findings across many topics in ubiquitin family. A few talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Major Topics:
1. Chromosomal DNA replication, replication fork stability
2. DNA repairs (excision repairs, dsDNA break repairs, DNA recombination)
3. DNA damage response
4. Epigenetic regulation, histone remodeling, genome structure
5. Chromosomal segregation
6. Human diseases

Keynote Speakers:
Wei Yang, National Institutes of Health , USA
Abstract title: Mechanism for DNA lesion recognition, repair and tolerance
Stephen West, The Francis Crick Institute, UNITED KINGDOM

Abstract title: Making and breaking recombination intermediates

Invited Speakers:
Hiroyuki Araki, National Institute of Genetics, JAPAN
Abstract title: Bidirectional initiation of chromosomal DNA replication in budding yeast
Michael Botchan, University of California, Berkeley, USA
Abstract title: The structure of ORC and new thoughts on how the initiator finds Chromosomes
Keith Caldecott, University of Sussex, UNITED KINGDOM
Abstract title: Regulation and Assembly of DNA Strand Break Repair Protein Complexes Associated with Human Genetic Disease
Judith Campbell, Caltech, USA
Anthony Carr, University of Sussex, UNITED KINGDOM
Abstract title: Mechanisms of replication-associated genome rearrangement
Junjie Chen, The University of Texas MD Anderson Cancer Center, USA
Abstract title: Protein-protein interaction network in DNA damage response and tumorigenesis
Yunje Cho, Pohang University of Science and Technology, SOUTH KOREA
Abstract title: Structural mechanism of Double Strand Break Repair by the Mre11 complex
David Cortez, Vanderbilt University School of Medicine, USA
Abstract title: ETAA1 acts at stalled replication forks to maintain genome integrity
Li-Lin Du, National Institute of Biological Sciences, Beijing, CHINA
Abstract title: Snf2-family protein Rrp2 confers etoposide resistance through counteracting SUMO-targeted ubiquitin E3 ligase
Fumio Hanaoka, Gakushuin University, JAPAN
Abstract title: Cancer and translesion synthesis polymerases: with special reference on UV-induced mutagenesis
Yue-jin Hua, Zhejiang University, CHINA
Abstract title: Progress in Molecular Mechanisms of Radioresistance in Deinococcus radiodurans
Jun Huang, Zhejiang University, CHINA
Abstract title:SUMO-mediated regulation of homologous recombination repair
Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA
Abstract title: Protecting the genome by homologous recombination
Daochun Kong, Peking University, CHINA
Abstract title: Replication fork formation and fork stabilization in eukaryotic cells
Stephen Kowalczykowski, University of California, Davis, USA
Abstract title: Molecular Functions of BRCA1, BRCA2, and RAD51 Paralogs in Homologous Recombination
Thomas Kunkel, NIEHS. NIH, USA
Abstract title: Generating and correcting nuclear DNA replication errors in yeast
Hitoshi Kurumizaka, Waseda University, JAPAN
Abstract title: Altered structures and physical characteristics of nucleosomes containing cancer-associated histone mutations
Li Lan, University of Pittsburgh, USA
Abstract title: Transcription-coupled recombinational repair upon damage
Guo-Min Li, University of Southern California, USA
Abstract title: Error-prone processing of DNA heteroduplexes by mismatch repair
Chuan-Yuan Li, Duke University Medical Center, USA
Abstract title: Unexpected roles of caspases, DNA double strand breaks, and DNA damage response in facilitating carcinogenesis and sustaining tumorigenicity
Lei Li, MD Anderson Cancer Center, USA
Abstract title: Fanconi Anemia and Cellular Response to DNA Replication Stress
David Lilley, University of Dundee, UNITED KINGDOM
Abstract title:The structure of the eukaryotic Holliday junction-resolving enzyme GEN1 bound to DNA
Cong Liu, Sichuan University West China Second University Hospital, CHINA
Abstract title: Wdr70 promotes long-range resection by stimulating histone H2B monoubiquitination
Yilun Liu, City of Hope, USA
Abstract title:Preventing Topoisomerase I – induced DNA breaks during transcription by the RECQ5 helicase
Zhenkun Lou, Mayo Clinic, USA
Abstract title: Regulation of the BRCA2-Rad51 pathway by ubiquitination signaling
Nancy Maizels, University of Washington, USA
Abstract title: Repair at DNA nicks
Hisao Masai, Tokyo Metropolitan Institute of Medical Science, JAPAN
Abstract title: Interaction with G-quadruplex structures forms a basis for Rif1-mediated regulation of DNA replication, transcription and chromatin architecture
Hisao Masukata, Osaka University, JAPAN
Abstract title: Control of replication timing and subnuclear localization by telomere binding proteins in fission yeast
Johanne Murray, University of Sussex, UNITED KINGDOM
Abstract title: The Smc5/6 complex and replication stress
Ketan Patel, University of Cambridge, UNITED KINGDOM
Abstract title: Alcohol and endogenously derived aldehydes mutate the genomes of blood stem cells
Tanya Paull, The University of Texas at Austin, USA
Abstract title: Processing of protein-DNA lesions in eukaryotic cells
John Petrini, Memorial Sloan Kettering Cancer Center, USA
Abstract title: The Mre11 interaction domain of Nbs1 is necessary and sufficient for Mre11 complex functions
Binghui Shen, Beckman Research Institute of the City of Hope, USA
Abstract title: Structure-specific nucleases in life and in death
Zhiyuan Shen, Rutgers Cancer Institute of New Jersey, USA
Abstract title: Confounding roles of essential caretaker genes in tumorigenesis: new insights gained from reversible BCCIP-deficiency mouse models.
Akira Shinohara, Osaka University, JAPAN
Abstract title: Control of meiotic recombination by Rad51/Dmc1 mediators and DNA helicases
Jeremy Stark, Beckman Research Institute of the City of Hope, USA
Abstract title: Factors that influence the outcome of mammalian chromosomal break repair
Patrick Sung, Yale University School of Medicine, USA
Abstract title: Role of the RAD51-RAD51AP1-UAF1 Complex in Homologous Recombination
Zhaoqi Wang, Leibniz Institute for Age Research, GERMANY
Abstract title: DNA damage response and neurodevelopment
Yinsheng Wang, University of California Riverside, USA
Abstract title: Novel Shuttle Vector-based Methods for Assessing the Transcriptional and Replicative Bypass of DNA Lesions in Cells
Xiaohua Wu, The Scripps Research Institute, USA
Abstract title: Regulation of DNA Double-Strand Break Repair in mammalian cells
Wei Xiao, Capital Normal University, CHINA
Abstract title: PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints
Guoliang Xu, Institute of Biochemistry and Cell Biology, CAS, CHINA
Abstract title: Enzymatic Oxidation of Methylcytosine in Mammalian Genomic DNA
Xingzhi Xu, Capital Normal University, CHINA
Abstract title: CLASPIN deubiquitination modulates ATR-dependent CHK1 activation in response to replication stress
Yungui Yang, Beijing Institute of Genomics, CAS, CHINA
Abstract title: RNA Epigenetics control of DNA Double-Strand Breaks Repair
Akira Yasui, Tohoku University School of Medicine, JAPAN
Abstract title: Chromatin remodeling for DNA double-strand break repair and transcriptional repression
Yuxin Yin, Peking University, CHINA
Abstract title: PTEN Family Regulates DNA Replication and Metabolism
Xiaochun Yu, City of Hope, USA
Abstract title: An endogenous PARP inhibitor
Shan Zha, Columbia University, USA
Abstract title: Role of ATM, DNA-PKcs and ATR in DNA repair – go beyond signaling
Xiaolan Zhao, Memorial Sloan Kettering Cancer Center, USA
Abstract title: Smc5/6- and SUMO-based regulation of recombination intermediate metabolism
Binbing Zhou, Shanghai Jiao Tong University School of Medicine, CHINA
Abstract title: De Novo Purine biosynthesis in Drug Resistance and Tumor Relapse of Childhood AL
Jin-Qiu Zhou, Institute of Biochemistry and Cell Biology, CAS, CHINA
Abstract title: The KEOPS complex regulates telomere replication and recombination independently of tRNA modification
Weiguo Zhu, Shenzhen University, CHINA
Abstract title: Lysine methyltransferases and demethylases in controlling DNA repair, genome stability and cell survival
Lee Zou, MGH Cancer Center/Harvard Medical School, USA

Abstract title: Novel Functions of RPA as a Sensor of Genomic Instability

We encourage abstracts to contain new and unpublished materials. The abstracts must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers. Status (fellow's talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers. 

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. A certain number of presentations by graduate students and postdocs in this conference will be selected as fellowship (USD $100-$500) awards. For more details, please visit Stipends

We look forward to seeing you at Suzhou in April, 2016.

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Late Registration

Payment Deadline:

May 16, 2016

Payment Deadline:

Before Arrival





















Please kindly note:

1. Registration includes food, but does NOT include Housing. Due to requests from participants to provide more housing at lower prices, we have expanded our housing options to include some lower priced nearby hotels. After completing the online registration, you will receive a link to the full list of housing options.
*Reference Room Rate:
CNY 500 per standard room per night in the Conference Hotel (Worldhotel Grand Dushulake Suzhou)
Up from CNY 200 per standard room per night in nearby budget hotels (within 5 km)
CNY 400-700 per standard room per night in nearby 4-5 star hotels

2. The meeting registration is an integral package. We encourage all our participants to stay for the full meeting period and communicate with each other. No refund/discount or day pass is available for partial participation.

3. The early price will be available if the full payment is finished before the exact due date.
For USD participants, we will automatically change your package price to the update one if we could not successfully charge the payment from your registered credit card before the deadline.
For CNY participants, we will automatically change your package price to the update one if our bank account could not receive your full payment by wire transfer before the deadline.

4. For late registrations, your registration materials may not be guaranteed since the order is usually made in advance.

5. Please inform us your special request on food (vegetarian, kosher…etc.) or other things during the online registration or email us as early as possible so that we could make relevant arrangement accordingly.

6. Student package is exclusively designed for all the graduate, undergraduate and doctor students who have not received the doctor degree. (Student ID will be required upon arrival).

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