Small GTPases at Different Scales:
Proteins, Membranes, Cells

Suzhou Dushu Lake Conference Center
September 24 - 28, 2012
Abstract deadline extended to July 31

Schedule Overview

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Organized by:
Jianping Ding, Shanghai Institutes for Biological Sciences, CAS, China
Klaus Gerwert, Ruhr-University Bochum, Germany/PICB, CAS, China
Roger Goody, Max Planck Institute, Germany
Shuh Narumiya, Kyoto University, Japan

We are pleased to announce the Cold Spring Harbor Asia conference on Small GTPases at Different Scales: Proteins, Membranes, Cells which will be held at the Suzhou Dushu Lake Conference Center in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday September 24, and will conclude after lunch on Friday September 28, 2012.

The conference will include eight oral sessions and one poster session. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Major Topics:
1. Biomolecular simulations and model systems for GTP hydrolysis
2. Molecular mechanism of GTP hydrolysis by small GTPases and their associated GAPs
3. Posttranslational modifications of small GTPases
4. Interactions of small GTPases with membranes
5. Protein-Protein interactions of small GTPases in vitro
6. Dynamics and Trafficking of small GTPases in vivo
7. Lessons from other GTPases for small GTPases
8. Small GTPases in disease and drugs for small GTPases

Keynote Speakers:
TBA

Invited Speakers:
Klaus Aktories, University of Freiburg, GERMANY
Abstract title: Rho GTPases as targets of bacterial protein toxins
Xiao-Wei Chen, University of Michigan, USA
Abstract title: Small GTPase in Metabolic Control: A Tale of GAP and GEF for Ral.
Channing Der, University of North Carolina at Chapel Hill, USA
Abstract title: Therapeutic strategies for targeting aberrant Ras and Rho small GTPase signaling for cancer treatment
Jianping Ding, Shanghai Institutes for Biological Sciences,CAS, China
Abstract title: Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 within the TORC1 activatory EGO complex
Mitsunori Fukuda, Tohoku University, Graduate School fo Life Sciences, Japan
Abstract title: The Rab family small GTPases regulate membrane trafficking in melanocytes
Klaus Gerwert, Ruhr-University Bochum, Germany /PICB, CAS, China
Abstract title:Catalysis of small GTPases by their respective GAP`s
Roger Goody, Max Planck Institute, GERMANY
Abstract title: The structural and mechanistic basis for Rab cycling and targeting
Alemayehu Gorfe, University of Texas Medical School - Houston, USA
Abstract title: Computational studies of Ras dynamics, membrane binding and assembly
Andrew Goryachev, University of Edinburgh, Center for Systems Biology, United Kingdom
Abstract title: Cdc42 dynamics explains the emergence of septin ring in budding yeast
John Hancock, University of Texas, USA
Abstract title:Spatiotemporal control of Ras plasma membrane interactions
Christian Herrmann, Ruhr-University Bochum, GERMANY
Abstract title: Nucleotide hydrolysis triggers major structural changes in human guanylate binding protein 1 (hGBP1)
Hans Robert Kalbitzer, University of Regensburg, GERMANY
Abstract title: Targeting excited states by small molecules – a new strategy for modulating the activity of small GTPases
Yoel Kloog, Tel Aviv University ISRAEL
Abstract title: Ras chaperons for cancer therapy
Toshimasa Ishizaki, Kyoto University, JAPAN
Abstract title: Liprin-a suppresses Rho-mDia mediated stress fiber formation.a
David Lambright, University of Massachusetts Medical School, USA
Abstract title: Structural insights into mechanisms for acceleration of GTP hydrolysis by Rab GAPs from host and pathogen perspectives
Fang-Jen Lee, National Taiwan University, TAIWAN
Abstract title: Spatio-temporal regulation of GTP exchange and hydrolysis of Arl1p at the late-Golgi
Zhenge Luo, Shanghai Institute of Neuroscience, SIBS, CAS, CHINA
Abstract title: Rab10 controls biogenesis of plasmalemmal precursor vesicles and asymmetric membrane addition during neuronal polarization
Edward Manser, Institute of Medical Biology, SINGAPORE
Abstract title: TBA
Didier Marguet, INSERM-CNRS de Marseille-Luminy, FRANCE
Abstract title: Fast scouting of K-Ras4B at the plasma membrane of living cells by spot variable Fluorescence Correlation Spectroscopy
Shuh Narumiya, Kyoto University, JAPAN
Abstract title: Rho-mDia Pathway in the cell, the tissue and the body.
Alexander Nemukhin, M.V.Lomonosov Moscow State University, RUSSIA
Abstract title: Modeling chemical steps of enzymatic hydrolysis of GTP
Mark Philips, New York University Cancer Insitute, USA
Abstract title: The RA and PH Domains of RIAM Act as a Proximity Detector for Rap1 and PI(4,5)P₂
Xiaochen Wang, National Institute of Biological Sciences, CHINA
Abstract title: "Rab GTPases function coordinately to regulate phagosome maturation in C. elegans"
Arieh Warshel, University of Southern California, USA
Abstract title: The nature of the activation of GTPases: Simulating the alosteric action of G-Proteins
Michael White, UT Southwestern Medical Center, USA
Abstract title: Coordination of cellular growth and self-renewal programs by Ras-like GTPases and the Exocyst.
Roland Winter, TU Dortmund, GERMANY
Abstract title: Gibbs energy determinants of lipoprotein insertion into lipid membranes: The case study of Ras proteins
Yanhui Xu, Fudan University, China
Abstract title: Structural insight into the Rag GTPase mediated mTOR Complex 1 activation
Xuewu Zhang, University of Texas Southwestern Medical Center, USA
Abstract title: Regulation and signaling of plexin: a tale of two dimers and two small GTPases

We encourage abstracts to contain new and unpublished materials. The abstracts must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers. Status (fellow's talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

Fellowship:
We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. A certain number of presentations by graduate students and postdocs in this conference will be selected as fellowship (USD $200-$500) awards. For more details, please visit Stipends

We look forward to seeing you at Suzhou in September.

Package Content:

Please kindly note:

1. The early & normal price will be available if the full payment is finished before the exact due date.
For USD participants, we will automatically change your package price to the update one if we could not successfully charge the full payment from your registered credit card before the deadline.
For CNY participants, we will automatically change your package price to the update one if our bank account could not receive your full payment by wire transfer before the deadline.

2. For Student Package registered participants, please add your roommate requirement during the online registration. Otherwise, we’ll assign you a roommate among other student participants.

3. For late registrations, your housing & registration materials may not be guaranteed since the order is usually made in advance.

4. Please inform us your request on extra day (USD 80/CNY 500 per day) and food (vegetarian, kosher…etc.) during the online registration or email us as early as possible so that we could make relevant arrangement accordingly.

5.We offer CSHA endowed student package for graduate students (student ID is required). This special offer only includes the meeting session pass. Housing, food and social activities are not included in the package.

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