Dynamics of Cellular Behavior During
Development and Disease

Suzhou, China
November 17-21, 2014
Abstract Deadline extended to: September 28th, 2014

Schedule Overview

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Organized by:
Zhengjun Chen, Institute of Biochemistry and Cell Biology, SIBS, China
Senthil Muthuswamy, University of Toronto, Canada
Shigeo Ohno, Yokohama City University School of Medicine, Japan
Alpha Yap, The University of Queensland, Australia


We are pleased to announce Cold Spring Harbor Asia conference on Dynamics of Cellular Behavior During Development and Disease which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday November 17, and will conclude after lunch on November 21, 2014.

The conference will include eight oral sessions and one poster session covering the latest findings across many topics in the field of cell polarity. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Dynamic changes in cell behavior are fundamental determinants of tissue biology, encompassing cell division, growth, development, and tissue morphogenesis. Changes in cellular dynamics are also observed in all disease states including cancer. Many aspects of cell biology such as cell polarity, the cytoskeleton, tissue regeneration, cancer cell metastasis and axonal growth all contribute to the broadly focused topic of cellular dynamics. This conference will provide a focus for the many investigators working on various aspects of cellular dynamics. Key questions to be discussed will include the following: How do signaling networks spatially organize the cell into polarized structures? How do cell polarity, cell cytoskeleton, cell-cell, and cell-matrix adhesion signaling pathways and tissue microenvironment affect cellular dynamics during biological process such as cell migration, tissue morphogenesis, neuronal development, tissue regeneration and cancer? And what are the new technologies that we need to analyse cellular dynamics. By bringing together investigators from diverse disciplines we aim to develop new concepts to understand how regulation of dynamic cell behaviour contributes to health and disease.

Major Topics:
1. Cell Polarity and Development
2. Cell Polarity and Cancer
3. Vesicle Traffic
4. Dynamics of Cell – Cell interactions
5. Dynamics of Cell – Matrix interactions
6. Cell migration

Keynote Speakers:
James Nelson, Stanford University School of Medicine, USA
Abstract title:Adhesive Mechanisms in Multicellularity Across Scales from Atoms to Tissues

Invited Speakers:
Zhengjun Chen, Institute of Biochemistry and Cell Biology, SIBS, CAS, CHINA
Abstract title:Novel insight into angiogenesis: the tight junction protein occludin functions as an endocytic regulator for VEFGR2 and regulates endothelial cell migration
Peter Friedl, University of Wuerzburg, GERMANY
Abstract title:Plasticity of cancer cell invasion in vivo
Yasuyuki Fujita, Hokkaido University, JAPAN
Abstract title:EDAC: Epithelial Defense Against Cancer
Kathleen Green, Northwestern University, USA
Abstract title:Role of Desmosomes in Tissue Morphogenesis and Disease
Stephan Grill, Max Planck Institute of Molecular Cell Biology and Genetics, GERMANY
Abstract title:TBA
Patrick Humbert, Peter MacCallum Cancer Institute, AUSTRALIA
Abstract title:Disorderly conduct and disturbing the peace: How tissue organization regulates cancer progression
Zhenge Luo, Institute of Biochemistry and Cell Biology, SIBS, CAS, China
Abstract title:Membrane trafficking mechanisms underlying axon development
Fernando Martin-Belmonte, Centro de Biología Molecular Severo Ochoa (UAM-CSIC), SPAIN
Abstract title:Endocytosis regulates tissue patterning in epithelial tubular organs
Senthil Muthuswamy, University of Toronto, CANADA
Abstract title:Cell polarity and dynamics of cell behavior during morphogenesis and metastasis.
Shigeo Ohno, Yokohama City University School of Medicine, JAPAN
Abstract title:Regulation of epithelial cell polarity by PAR3 depends on Girdin transcription and Girdin-Galphai3 signaling
Guangshuo Ou, Institute of Biophysics,Chinese Academy of Science, China
Abstract title:Mechanisms of C. elegans Neuroblast Development
Michael Overholtzer, Memorial Sloan Kettering Cancer Center, USA
Abstract title:Competition between tumor cells by entosis.
Erik Sahai, London Research Institute, UK
Abstract title:Modelling cancer cell invasion in complex environments
Martin Schwartz, Yale School of Medicine, USA
Abstract title:Mechanotransduction and integrin signaling in the vascular system.
Lila Solnica-Krezel, Washington University in St. Louis, USA
Abstract title:Dchs1b mediates morphogenesis and cell fate specification in early zebrafish embryo through regulation of actin and microtubule cytoskeleton
Ulrich Tepass, University of Toronto, CANADA
Abstract title:Regulation and function of a-Catenin in Drosophila cell adhesion
Xuebiao Yao, University of Science and Technology of China, CHINA
Abstract title:Molecular delineation of ARF6-ACAP4 interaction dynamics underlying cancer cell metastasis
Alpha Yap, The University of Queensland, AUSTRALIA
Abstract title:Mechanical integration of epithelial tissues: the role of active cell-cell junctions.
Li Yu, Tsinghua University, CHINA
Abstract title:Autophagic lysosome reformation
Lixing Zhan, Shanghai Institute for Biological Sciences, CAS, CHINA
Abstract title:Loss of polarity protein AF6 promotes pancreatic cancer metastasis through inducing of Snail expression
Xueliang Zhu, Institute of Biochemistry and Cell Biology, SIBS, CAS, China
Abstract title:Centriole amplification during multiciliogenesis of epithelial cells

We encourage abstracts to contain new and unpublished materials. The abstracts must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers. Status (fellow's talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers.

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. A certain number of presentations by graduate students and postdocs in this conference will be selected as fellowship (USD $200-$500) awards. For more details, please visit Stipends

We look forward to seeing you at Suzhou in November 2014.

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Early Registration

Late Registration

Payment Deadline:

 October 20, 2014

Payment Deadline:

Before Arrival





















Please kindly note:

1. Registration includes food, but does NOT include Housing. Due to requests from participants to provide more housing at lower prices, we have expanded our housing options to include some lower priced nearby hotels. After completing the online registration, you will receive a link to the full list of housing options.
*Reference Room Rate:
CNY 500 per standard room per night in the Conference Hotel (Worldhotel Grand Dushulake Suzhou)
Up from CNY 200 per standard room per night in nearby budget hotels (within 5 km)
CNY 400-700 per standard room per night in nearby 4-5 star hotels

2. The early price will be available if the full payment is finished before the exact due date.
For USD participants, we will automatically change your package price to the update one if we could not successfully charge the payment from your registered credit card before the deadline.
For CNY participants, we will automatically change your package price to the update one if our bank account could not receive your full payment by wire transfer before the deadline. 3. For late registrations, your registration materials may not be guaranteed since the order is usually made in advance.

4. Please inform us your special request on food (vegetarian, kosher…etc.) or other things during the online registration or email us as early as possible so that we could make relevant arrangement accordingly.

5. Student package is exclusively designed for all the graduate, undergraduate and doctor students who have not received the doctor degree. (Student ID will be required upon arrival).

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