Bacterial Infection & Host Defense

Suzhou, China 
April 8-12, 2019 
Abstract deadline: February 18th, 2019

Conference Agenda

Organized by:

Elizabeth Hartland, Monash University, Australia

Kenya Honda, Keio University, Japan

Nina Salama, Fred Hutchison Cancer Research Center, USA

Feng Shao, National Institute of Biological Sciences, China

Jörg Vogel, Helmholtz Institute for RNA-based Infection Research, Würzburg, Germany

We are pleased to announce the Cold Spring Harbor Asia conference on the Cold Spring Harbor Asia conference on Bacterial Infection & Host Defense which will be held in Suzhou, China, located approximately 60 miles west of Shanghai. The conference will begin at 7:00pm on the evening of Monday April 8, and will conclude after lunch on Friday April 12, 2019.

The conference will include eight oral sessions and one poster session covering the latest findings across many topics in bacterial infection. Many talks will be selected from the openly submitted abstracts on the basis of scientific merit and relevance. Social events throughout the conference provide ample opportunity for informal interactions.

Major Topics:
1. Bacterial intracellular trafficking
2. Gene expression & virulence traits in pathogenic microbes
3. Host response to bacterial infection
4. Gastrointestinal colonization
5. The microbiome in health & disease
6. Bacterial toxins & pathogenesis
7. New approaches to investigating the host-pathogen interface
8. Cancer-associated microbes
9. Antibiotic resistance & novel anti-infectives

Keynote Speakers (Speaker, Affiliation, COUNTRY/Region):
Michael Gilmore, Harvard Medical School, USA
Abstract title:Enterococci: Ultimate model of microbial interaction with terrestrial hosts, and how the properties they evolved led to trouble in the antibiotic era
Scott Hultgren,
 Washington University School of Medicine, USA
Abstract title:UTI Complexity Results from Diversity at the Bacterial-Host Interface

Invited Speakers (Speaker, Affiliation, COUNTRY/Region):
Neal Alto, University of Texas Southwestern Medical Center, USA
Abstract title:Identification of cell intrinsic immune mechanisms that control bacterial and viral infection. 
Gilad Bachrach, The Hebrew University-Hadassah School of Dental Medicine, ISRAEL
Abstract title:Tumor targeting by Fusobacterium nucleatum
Clare Bryant, The University of Cambridge, UK
Abstract title:Pattern Recognition Receptors and the host response to Salmonella infection
Youjun Feng, Zhejiang University School of Medicine, China
Abstract title:Action and Mechanism for MCR Polymyxin Resistance
Yiping Han, Columbia University, USA
Abstract title:Mechanistic insight on Fusobacterium nucleatum in colorectal cancer – a "two-hit" model
Elizabeth Hartland, University of Melbourne, AUSTRALIA
Abstract title:EPEC and Shigella host cell interactions
Birgitta Henriques-Normark, Karolinska Institutet, SWEDEN
Abstract title:Pneumococcal interactions with the host
Thomas Henry, Inserm, France
Abstract title:Guanylate-binding Proteins and inflammasomes in the human defenses against Francisella tularensis
Jay Hinton, University of Liverpool, UK
Abstract title:Comparative transcriptomics identifies a single SNP mutation that controls virulence of African Salmonella
Kenya Honda, Keio University / RIKEN Center for Integrative Medical Sciences, JAPAN
Abstract title:Gut microbiota-targeted therapeutic strategy
Linda Kenney, University of Illinois, USA
Abstract title:Single cell, super-resolution imaging reveals acid-dependent SPI-2 gene regulation by SsrB
Tomoko Kubori, Gifu University, JAPAN
Abstract title:Manipulation of the host ubiquitin system by Legionella
Egil Lien, UMass Medical School, USA
Abstract title:Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death
Dena Lyras, Monash University, AUSTRALIA
Abstract title:Clostridium difficile infection induces colonic stem cell damage and impairs intestinal repair 
Samuel Miller, University of Washington, USA
Abstract title:Cyclic-di-GMP regulation promotes survival of a slow-replicating subpopulation of intracellular Salmonella Typhimurium
Indira Mysorekar, Washington University School of Medicine, USA
Abstract title:Molecular Crosstalk between Redox Stress and Autophagy Regulates Urothelial Defense Responses to Uropathogenic Escherichia Coli Infection
Anne O'Garra, The Francis Crick Institute, UK
Abstract title:Transcriptomics demonstrate type I interferons contribute to pathogenesis in tuberculosis and block protective responses to Mycobacterium tuberculosis and other bacteria
Vijay Rathinam, UConn Health School of Medicine, USA
Abstract title:Host Responses to Intracellular LPS: Pyroptosis & Beyond
Craig Roy, Yale University School of Medicine, USA
Abstract title:Modulation of host immunity by bacterial effector proteins
Nina Salama, Fred Hutchison Cancer Research Center, USA
Abstract title:Staying in shape: bacterial cytoskeleton-cell wall interactions in the gastric pathogen Helicobacter pylori
Karla Satchell, Northwestern University Feinberg School of Medicine, USA
Abstract title:Self regulating MARTX toxins suppress proinflammatory signaling in response to cytoskeletal collapse
Feng Shao, National Institute of Biological Sciences, CHINA
Abstract title:Innate immunity to cytosolic LPS: pyroptosis and beyond
Daniel Slade, Virginia Tech, USA
Abstract title:Reverse genetic engineering facilitates the identification of Fusobacterium nucleatum proteins critical for host cell binding, invasion and altered cell signaling
Jörg Vogel, Helmholtz Institute for RNA-based Infection Research, GERMANY
Abstract title:Taking the RNA route to a better understanding of Fusobacterium 

We encourage abstracts to contain new and unpublished materials. The abstracts must be submitted electronically by the abstract deadline. Selection of material for oral and poster presentation will be made by the organizers. Status (fellow's talk/poster) of abstracts will be posted on our web site as soon as decisions have been made by the organizers. 

We are eager to have as many young people as possible attend since they are likely to benefit most from this meeting. A certain number of presentations by graduate students and postdocs in this conference will be selected as fellowship (USD $100-$500) awards. For more details, please visit

We look forward to seeing you at Suzhou in April, 2019.

Sponsored by: